郭彩欣,博士,副教授,硕士生导师。2007年7月于中国科学院化学研究所获理学博士学位。现就职于纳米医药与生物传感器实验室。主要研究内容包括:1.纳米药物载体材料, 研究可用于药物缓控释和靶向输送的纳米药物载体材料;2纳米生物传感器,基于纳米探针构建生物传感器,用于检测水中重金属污染物及农药残留;3. 多功能造影剂及诊疗试剂的研究。构建具有声、光、磁等多功能的造影剂,同时研究具有医学诊断和治疗作用的多功能诊疗一体化试剂。先后主持国家自然科学基金、哈工大科研创新基金、国家重点实验室开放课题等项目。作为主要项目完成人,参与了国家自然基金、国家863、教育部高等学校科技创新工程等多个项目的研究工作。在国际期刊Biosensors and Bioelectronics, Langmuir, J. Phys.Chem B, Analyst 等杂志上发表SCI论文20余篇,申请发明专利2项。
专业:生物医学工程
联系电话:15045117648
电子信箱:163gcx@sina.com
通讯地址:哈尔滨工业大学437信箱
邮编:150001
简历
1997.97~2001.7东北师范大学化学学院,本科
2001.9~2004.7东北师范大学化学学院,硕士
2004.9~2007.7中科院化学所,博士
2007.7~2011.12哈尔滨工业大学,基础与交叉科学研究院,讲师
2011.12-至今哈尔滨工业大学,生命科学与技术学院,副教授
研究方向:
1.纳米药物缓控释载体材料的研究
2.纳米生物检测
3.多功能造影剂及诊疗试剂的研究
发表科研论文
1.Xiuli Yue,Caixin Guo, Yuanmiao Jing, Fang Ma and Zhifei Dai, Free-standing liposomal nanohybrid cerasomes as ideal materials for cupric ions sensing,Analyst, 2012, 137(9), 2027-2031.
2.Caixin Guo, Jinliang Wang, Jing Cheng, Zhifei Dai,Determination of trace copper ions with ultrahigh sensitivity and selectivity utilizing CdTe quantum dots coupled with enzyme inhibition,Biosensor and Bioelectronics, 2012, DOI: 10.1016/j.bios.2012.03.040.
3.Caixin Guo, Jinliang Wang, Zhifei Dai, Selective content release from light-responsive microcapsules by tuning the surface plasmon resonance of gold nanorods,Microchimica Acta, 2011, 173, 375-382.
4.Caixin Guo, Like Zeng, Shaoqin Liu, Qi Chen, Zhifei Dai, Xiaoyi Wu, In Vitro Evaluation and Finite Element Simulation of Drug Release from Polydiacetylene-Polyethylene Glycol Stearate Nanovesicles,J. Nanosci. Nanotech., 2012, 12, 245-251.
5.Hengte Ke, Jinrui Wang, Zhifei Dai, Yushen Jin, Enze Qu, Zhanwen Xing,Caixin Guo, Xiuli Yue, Jibin Liu, Gold nanoshelled microcapsules: a theranostic agent for ultrasound contrast imaging and photothermal therapy, Angewandte Chemie International Edition, 2011, 50(13), 3017-3021.
6.Hengte Ke, Jinrui Wang, Zhifei Dai, Yushen Jin, Enze Qu, Zhanwen Xing,Caixin Guo, and Xiuli Yue, Bifunctional gold nanorod-loaded polymeric microcapsules for both contrast-enhanced ultrasound imaging and photothermal therapy, Journal of Materials Chemistry, 2011, 21, 5561-5564。
7.Caixin Guo, Shaoqin Liu, Zhifei Dai, Chang Jiang, Wenyuan Li, Polydiacetylene vesicles as a novel drug sustained-release system,Colloids and Surfaces B: Biointerfaces, 2010, 76, 362-365.
8.Caixin Guo, Shaoqin Liu, Chang Jiang, Wenyuan Li, Zhifei Dai,Hiroe Fritz, Xiaoyi Wu, A Promising Drug Controlled-Release System Based on Diacetylene/Phospholipid Polymerized Vesicles,Langmuir, 2009, 25, 13114-13119.
9.Renzhe Zhang,Caixin Guo, Long Jiang, Tao Liu, The Fluorescence Recovery of Polydiacetylene/Fluorophore Vesicles by Interaction with Cetyltrimethylammonium Bromide,J. Nanosci. Nanotech., 2009, 9, 990-994.
10.Caixin Guo, Paul Boullanger, Long Jiang, Tao Liu, Highly Sensitive Gold Nanoparticles Biosensor Chips Modified with a Self-assembled Bilayer for Detection of Con A,Biosensor and Bioelectronics,2007, 22, 1830-1834.
11.Caixin Guo, Paul Boullanger, Long Jiang, Tao Liu, Colorimetric Detection of WGA in Carbohydrate -functionalized Polydiacetylene Langmuir–Schaefer Films,Colloids and Surfaces A: Physicochem.Eng.Aspects, 2007, 293, 152-156.
12.Caixin Guo, Paul Boullanger, Long Jiang, Tao Liu, One-Step Immobilization of Dodecanethiol/ Glycolipid Vesicles onto Gold Electrode: Amperometric Detection of Concanavalin A,Colloids and Surfaces B: Biointerfaces, 2008, 62, 146-150.
13.Caixin Guo, Renzhe Zhang, Long Jiang, Tao Liu,Investigation on the temperature effect of a mixed vesicle composed of polydiacetylene and BODIPY 558,Colloids and Surfaces B: Biointerfaces, 2007, 60, 41–45.
14.Cai X. Guo, Paul Boullanger, Tao Liu, and Long Jiang, Size Effect of Polydiacetylene Vesicles Functionalized with Glycolipids on Their Colorimetric Detection Ability,J. Phys. Chem. B,2005, 109, 8765-18771.
15.Caixin Guo, Minhua Cao, Changwen Hu,Synthesis and Characterization of Dy(OH)3 and Dy2O3 Nanotubes,J. Nanosci. Nanotech., 2005, 5, 184-187.
16.Caixin Guo, Minhua Cao, Changwen Hu, A Novel and Low-temperature Hydrothermal Synthesis of SnO2 Nanorods,Inorg. Chem. Commun., 2004, 7, 929-931.
17.Jieli Deng,Caixin Guo, Wensheng Lu, Tao Liu, Long Jiang, Polydiacetylene Vesicles A Biomolecular Recognition Device based on Molecular Assembly,Progress in Chemistry, 2006, 18, 1397-1408.
18.Yonghui Wang,Caixin Guo, Y. W. Chen, Changwen Hu, W. H. Yu, Self-assembled Multilayer Films Based on a Keggin-type Polyoxometalate and Polyaniline,J. Colloid and Interface Science.,2003, 264, 176.
19.Minhua Cao,Caixin Guo, Yanjuan Qi, Changwen Hu, Enbo Wang, A Simple Route towards CuO Nanowires and Nanorods,J. Nanosci. Nanotech., 2004, 4, 829-832.
20.Cao MH, Wang YH,Guo CX, Qi YJ, Hu CW, Wang EB, A simple route towards CuO nanowires and nanorods,J. Nanosci. Nanotech., 2004, 4, 824-828.
21.Cao MH, Wang YH,Guo CX, Qi YJ, Hu CW, Preparation of ultrahigh-aspect-ratio hydroxyapatite nanofibers in reverse micelles under hydrothermal conditions,Langmuir, 2004, 20, 4784-4786.
22.Li DF, Gu CZ,Guo CX, Hu CW, The effects of ambient gases on the surface resistance of polyoxometalate/TiO2 film,Chem. Phys. Lett., 2004, 385, 55-59.
科研项目
1.国家自然科学基金(No.81101094):新型超声/CT双功能造影剂的制备及在肿瘤诊断中的应用研究(2012.01-2014.12),23万,负责
2.校创新基金(No. AUWQ18400004):基于癌症诊治的联乙炔聚合类脂体靶向给药体系(2008.6-2009.6),3.5万,负责
3.校博士后资助经费(No. AUGA41400030):可聚合类脂体靶向药物输送体系的体内外评价(2008.8-2010.8),4万,负责
4.国家自然科学基金面上项目(No.20977021):水源水体中环境激素的高灵敏快速荧光检测技术(2010.1-2012.12),36万,第二
5.哈工大国家重点实验室开放基金(No.ES201003):基于量子点荧光猝灭结合酶抑制法快速检测水中的重金属污染物的研究(2010.7-2012.7),5万,负责
6.国家自然科学基金青年基金(No.81000673):新型免疫隔离屏障SGX微囊的制备及在异种胰岛移植中的实验研究(2011.1-2013.12),20万,第二
7.城市水资源与水环境国家重点实验室自主课题(No. 2009TS01):水环境中持久性有机污染物的快速检测关键技术(2009.6至2011.5年),20万,第三
8.国家863计划(No. 2007AA03Z316):癌症诊治用仿细胞膜纳米载体材料与技术(2007.1至2010.11年),92万,第六
9.教育部高等学校科技创新工程重大项目培育资金项目(No. 707021),基于瓷质体的新型药物靶向可控释放技术(2008.1至2009.12年),40万,第六