姓名:费嘉 性别:男
职称:教授 学院:医学院
研究方向:(1)小核酸药物筛选与肿瘤基因治疗.,(2)肿瘤非编码RNA(Non-Coding RNAs)功能研究等
导师简介:
医学博士、分子生物学博士后,Memorial Sloan Kettering Cancer Center
访问学者,email: efeijia@163.com. 研究方向(1)小核酸药物筛选与肿瘤基因治疗.
(2)肿瘤非编码RNA(Non-Coding RNAs)功能研究. (3)生物芯片与生物信息学研究.
《医学分子生物学》编委(高等教育出版社2008). 暨南大学研究生“医学分子生物学”精品
课程负责人. 广东省自然科学基金评审专家.国际杂志特约审稿专家(1) J Drug Target
(2) Oligonucleotides(3)Acta Pharmacologica Sinica
【主持科研项目】近五年主持国家、省部科研项目十项。
【获奖情况】
1.2010年度广东省科学技术奖(技术发明三等奖): 以mRNAs和microRNAs为靶标的反
义寡核苷酸设计及抗肿瘤实验研究。项目编号: B14-0-3-02 (项目负责人)
2.2009年度广东省科学技术奖(自然科学三等奖): 靶向抑制VEGF等癌基因表达对髓系白
血病化疗增敏效应研究. 项目编号:A04-0-3-02.(项目负责人)
3.2007美国癌症研究协会(AACR)“The Role of Non-Coding RNAs in Cancer.”
会议授于AACR-AstraZeneca International Scholar-in-Training Award
【代表性论文】
1.miR-181a post-transcriptionally downregulates oncogenic RalA and contributes to cell growth inhibition, G2 phase arrest and apoptosis in chronic myelogenous leukemia (CML) cells(submitted, corresponding author)
2.Inhibition of small GTPase RalA regulates growth, cell cycle and arsenic-induced apoptosis in chronic myeloid leukemia(CML) cell. Cellular Signalling(revised)(SCI, IF 4.243, A1, corresponding author)
3.Anti-miR-21 Oligonucleotide Sensitizes Leukemic K562 Cells to Arsenic Trioxide By Inducing Apoptosis. Cancer Science.2010,101(4): 948–954 Epub 2010 Jan 7(SCI, IF 3.846, A1, corresponding author)
4.Antisense oligonucleotide against miR-21 inhibites growth, migration and induces apoptosis in leukemic K562 cells. Leukemia and Lymphoma 2010, 51(4):694-701 Epub 2010 Feb 8. (SCI, IF 2.492, A2, corresponding author )
5.Anti-miR-21 oligonucleotide enhances chemosensitivity of leukemic HL60 cells to arabinosylcytosine by inducing apoptosis. Hematology. 2010 Aug;15(4):215-221. (SCI, IF 1.336, A2, corresponding author )
6.miRNA-21 regulates arsenic-induced anti-leukemia activity in myelogenous cell lines. Med Oncol 2011 Mar;28(1):211-8. Epub 2010 Feb 9. (SCI, IF 2.21, A2, corresponding author)
7.Inhibitory effects of anti-miRNA oligonucleotides (AMOs ) on A549 cell growth. J Drug Target. 2008,16(9 ) 688-693.(SCI,IF 2.491,A2)
8.Prediction of VEGF mRNA antisense oligodeoxynucleotides by RNA Structure software and their effects on HL60 and K562 cells. CELL BIOL INT. 2005,29(9) 737- 741(SCI,IF 1.747)