姓名：黎孟枫 性别：男 职称：教授
学院：医学院 最后学历：博士
主要研究方向：病毒致癌与肿瘤发生的分子机制；分子病毒学与分子肿瘤学
个人简介
“长江学者”特聘教授，中山大学副校长兼中山医学院院长。1986年毕业于中山医科大学临床医学专业毕业，获医学学士学位。1986－1991年就读中山医科大学与中国预防医学科学院北京病毒学研究所（CAPM－BIV）病毒基因工程国家重点实验室联合培养研究生，获医学博士学位。1991－1993年任CAPM-BIV病毒基因工程国家重点实验室助理研究员。1993年前往美国匹兹堡癌症研究所接受博士后训练，并于1997年在该所担任研究助理教授（Research Assistant Professor，非独立职位）。2000年起受聘于匹兹堡大学医学院病理系，任助理教授(Assistant Professor，独立职位)，一直在美国从事医学分子病毒学、分子肿瘤学和细胞生物学的教学与科研，研究领域主要为病毒致病与致癌、以及肿瘤发生发展的分子机制，并讲授医学生“Molecular Pathogenesis of Infectious Diseases”和博士生“Angiogenesis: Physiology and Pathological Significance”课程。2005年受聘为“长江学者”特聘教授，全职归国到中山医学院工作。黎孟枫教授近年在中山大学主要致力于阐明肿瘤发生与病毒感染、炎症过程的关系，以及相关的信号控制机理，主要学术重点是NF-κB信号通路所涉及的新调控分子及其工作机制，以及由此产生的生物学效应和在肿瘤、病毒性疾病上的临床意义，最近发现了NF-κB的激活与多种病毒感染相关基因之间的相互作用，以及miRNA对NF-κB激活的表观遗传学调控作用，深入研究了这些相互作用的生物学意义。作为上述调控网络的理论意义的延伸，还研究了NF-κB调控分子在病毒感染和肿瘤恶化中的临床意义，并在此基础上寻找病毒感染和恶性肿瘤诊断、预后判定新分子标志物及治疗新靶点。上述研究的部分结果最近发表在Cancer Research., Oncogene, Journal of Pathology, American Journal of Pathology, Clinical Cancer Research等期刊上。
学术论著与教材：近三年发表的学术论文：
1. Jun Li, Nu Zhang, Li Bing Song, Wen Ting Liao, Li-Li Jiang, Li YunGong, Wu JH, Jie Yuan, Hui Zhong Zhang, Mu Shen Zeng, Mengfeng Li*. Astrocyte elevated gene-1 Is a Novel Prognostic Marker for Breast Cancer Progression and Overall Patient Survival. Clinical Cancer Research. 14(11): 3319-3326, 2008.
2. Jun Li, Hong-Yu Guan, Li-Yun Gong, Li-Bing Song, Nu Zhang, Jueheng Wu, Jie Yuan, Yi-Jie Zheng, Zheng-Song Huang, *Mengfeng Li. Clinical Significance of Sphingosine Kinase-1 Expression in Human Astrocytomas Progression and Overall Patient Survival. Clin. Cancer Res. 14(21): 6996-7003, 2008.
3. J Li, L Yang, L Song, H Xiong, L Wang, X Yan, J Yuan, J Wu, Mengfeng Li*. Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1. Oncogene, 28(36): 3188-3196, 2009.
4. Jun Li, Liang Yu, Huizhong Zhang, Jueheng Wu, Jie Yuan, Xiaoxi Li*, Mengfeng Li*. Down-regulation of pescadillo inhibits proliferation and tumorigenicity of breast cancer cells. Cancer Science, 100 (12): 2255-2260, 2009. [Epub 2009 Aug 25].
5. Li-Bing Song, Jun Li, Wen-Ting Liao, Yan Feng, Chun-Ping Yu, Li-Juan Hu, Qing-Li Kong, Li-Hua Xu, Xing Zhang, Wan-Li Liu, Man-Zhi Li, Ling Zhang, Tie-Bang Kang, Li-Wu Fu, Wen-Lin Huang, Yun-Fei Xia, Sai Wah Tsao, Mengfeng Li, Vimla Band, Hamid Band, Qing-Hua Shi, Yi-Xin Zeng, and Mu-Sheng Zeng*. The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. Journal of Clinical Investigation, 119(12): 3226-3236, 2009.
6. Fan Liu, Qing Li, Hong Yang, Xiao-Ling Cai, Xue-Kui Xia, Sheng-Ping Chen, Mengfeng Li, Zhi-Gang She∗ and Yong-Cheng Lin*. Structure elucidation of three diphenyl ether derivatives from the mangrove endophytic fungus SBE-14 from the South China Sea. Magnetic Resonance in Chemistry. 47: 453–455, 2009.
7. Wen Li, Chun-Ping Yu, Jin-tang Xia, Ling Zhang, Gui-Xiang Weng, Hai-qing Zheng, Qing-li Kong, Li-juan Hu, Mu-Sheng Zeng, Yi-xin Zeng, Mengfeng Li, Jun Li*, and Li-Bing Song*. Sphingosine Kinase 1 Is Associated with Gastric Cancer Progression and Poor Survival of Patients. Clin Cancer Res. 15:1393-1399, 2009.
8. Fan Liu, Xiao-Ling Cai, Hong Yang, Xue-Kui Xia, Zhi-Yong Guo, Jie Yuan, Mengfeng Li, Zhi-Gang She, Yong-Cheng Lin*. The Bioactive Metabolites of the Mangrove Endophytic Fungus Talaromyces sp. ZH-154 Isolated from Kandelia candel (L.) Druce. Planta Medica, 75: 1–4, 2009.
9. Jun Li, Heng Zhang, Jueheng Wu, Hongyu Guan, Jie Yuan, Zhengsong Huang, Mengfeng Li*. Prognostic Significance of Integrin-linked kinase1 Overexpression in Astrocytoma. International Journal of Cancer, 126(6): 1436-1444, 2010. [Epub 2009 Oct 15].
10. Jun Li, Li-Yun Gong, Li-Bing Song, Li-Li Jiang, Li-Ping Liu, Jueheng Wu, Jie Yuan, Jun-Chao Cai, Mian He, Lan Wang, Musheng Zeng, Shi-Yuan Cheng*, Mengfeng Li*. Oncoprotein Bmi-1 Renders Apoptotic Resistance to Glioma Cells through Activation of the IKK-NF-kB Pathway. American Journal of Pathology 176(2): 699-709, 2010. [Epub 2009 Dec 24].
11. Liping Liu, Jueheng Wu, Zhe Ying, Baixue Chen, Libing Song, Jie Yuan, Jun Li*, Mengeng Li*. Astrocyte elevated gene-1 (AEG-1) Upregulates Matrix Metalloprotease-9 and Induces Human Glioma Invasion. Cancer Research, 70(9): 3750-3759, 2010. [Epub 2010 Apr 13].
12. Xu Chen, Jueheng Wu, Hanning Liu, Zhenjian He, Minghui Gu, Ning Wang, Jianda Ma, Jieping Hu, Lei Xia, Haipeng He, Jie Yuan, Jun Li, Luyuan Li, Mengfeng Li*, Xun Zhu*. Approaches to efficient production of recombinant angiogenesis inhibitor rhVEGI-192 and characterization of its structure and antiangiogenic function. Protein Science. 19(3): 449-57. 2010.
13. Gui’e Xie, Xun Zhu, Qing Li, Zhenjian He, Jueheng Wu, Jun Li, Yongcheng Lin, Mengfeng Li, Zhigang She*, Jie Yuan*. SZ-685C, a marine anthraquinone, as a potent apoptosis inducer with anticancer activity through suppressing the Akt/FOXO pathway. British Journal of Pharmacology, 159 (3): 689-697, 2010. [Epub 2010 Jan 28].
14. Libing Song*, Lan Wang, Jun Li, Huaping Xiong, Jueheng Wu, Menfeng Li*. Sam68 Upregulation Correlates with, and Its Downregulation Inhibits, Proliferation and Tumorigenicity of Breast Cancer Cells. Journal of Pathology, 222 (3): 227–237, 2010. [Epub online July 27, 2010]. 【Commented in the same issue of Journal of Pathology by David J Elliott and Prabhakar Rajan: The role of the RNA-binding protein Sam68 in mammary tumourigenesis. 222: 223–226, 2010.】
15. Xiaofan Ding, Lifang Jiang, Changwen Ke, Zhan Yang, Chunliang Lei, Kaiyuan Cao, Jun Xu, Lin Xu, Xingfen Yang, Yonghui Zhang, Ping Huang, Weijun Huang, Xun Zhu, Zhenjian He, Liping Liu, Jun Li, Jie Yuan, Jueheng Wu, Xiaoping Tang*, Mengfeng Li*. Amino acid sequence analysis and identification of mutations under positive selection in hemagglutinin of 2009 influenza A (H1N1) isolates. Virus Genes, 41:329–340, 2010.【Epub 2010 Aug 31, DOI 10.1007/s11262-010-0526-z】.
16. Hongyu Guan, Heng Zhang, Jueheng Wu, Jie Yuan, Zhengsong Huang* and Mengfeng Li*. IKBKE is overexpressed in glioma and contributes to resistance of glioma cells to apoptosis via activating NF-κB. Journal of Pathology. Journal of Pathology, 223: 436–445. 2011
17. Libing Song*, Huaping Xiong, Jun Li, Wengting Liao, Lan Wang, Jueheng Wu, Menfeng Li*. Sphingosine kinase-1 Enhances Resistance to Apoptosis through Activation of PI3K/Akt/NF-κB Pathway in Human Non-small Cell Lung Cancer. Accepted by Clinical Cancer Research. 2011
18. Hongyu Guan, Junchao Cai, Nu Zhang, Jueheng Wu, Jie Yuan, Jun Li and Mengfeng Li*. Sp1 is upregulated in human glioma, promotes MMP-2-mediated cell invasion and predicts poor clinical outcome. Accepted by International Journal of Cancer. 2011.
学术兼职：
黎孟枫教授现还担任国务院学位委员会学科评议组（基础医学）成员、中国微生物学会《病毒学报》副总编、美国癌症学会会员、美国微生物学会会员、国际自然免疫学会会员等学术兼职。
其 他：主持在研基金项目：
1. 微小RNA与肿瘤，973课题
2. 海洋来源的抗肿瘤候选药物SZ-685C的研究，国家新药科技重大专项
3. 广东省传染病病原谱流行规律研究（监测平台），国家传染病科技重大专项
4. 原癌基因AEG-1诱导乳腺癌早期转移的分子机制，国家自然科学基金面上项目
5. 驱动脑胶质瘤血管新生的新机制：AEG-1激活的信号转导，国家自然科学基金面上项目