姓名：毕惠嫦 性别：女 出生年月：1975年1月
职称：副教授 学院：药学院 最后学历：博士
主要研究方向：药物代谢组学、药代动力学、临床药理学
女，1975年1月出生。中山大学药学院 药物代谢与药动学实验室、中山大学临床药理研究所副教授、硕士生导师，中山大学药学院教学指导委员会委员。1997年毕业于中国药科大学获学士学位，2007年毕业于中山大学获博士学位并留任于药学院，2011年至2012年于美国国立卫生研究院、国家癌症研究所（NCI/NIH）进行博士后研究工作。研究方向与专长为药物代谢组学、药代动力学、临床药理学，专注于研究临床常用中药制剂与配伍西药之间的相互作用机制及相关代谢酶、转运蛋白影响下的临床合理用药。熟悉新药开发临床前研究ADME，熟悉药物代谢组学研究的检测技术如UPLC-ESI-QTOFMS，熟悉相关的数据分析与处理软件如Masslynx、SIMCA，熟悉代谢组学模式识别技术如SIMCA、PCA、PLS、PLS-DA等。目前主持国家自然科学基金、教育部博士点专项科研基金各1项，分题负责国家重点基础研究发展计划（973计划）课题1项，主持澳门大学研究基金1项，主持广东省中医药局课题、广东省医学科研基金、广州市科技局科技支撑等项目数项；参与国家“重大新药创制”重大专项（“十一五”项目）课题、国家自然科学基金、省级科研基金多项。已出版专著两部（主编、副主编），参编教材2部，>2004年以来在国内外期刊发表研究论文50多篇，其中SCI收录30多篇。
■ 学习经历
1993.09 ～ 1997.06： 中国药科大学，获英语药学学士学位
2002.09 ～ 2007.06： 中山大学药学院，获药理学博士学位
■ 工作经历
2007.07 ～ 至今 中山大学临床药理研究所、中山大学药学院药物代谢与药动学实验室
2011.10 ～2012.11 美国国立卫生研究院、国家癌症研究所（NCI/NIH）
■ 讲授课程
《临床药理学》，《生物药剂学与药物动力学》，《文献检索与论文写作》，《药学英语》。
■ 研究兴趣
1. 代谢组学、药物代谢组学
2. 药物代谢与药代动力学（药物相互作用）
3. 临床药理学
■ 科研基金（主持）
五酯片作为他克莫司节约药的物质基础及在CYP3A和P-gp通路的机制研究. 编号：81001685，国家自然科学基金（青年科学基金项目），20万元，2011.01～2013.12，负责。
五酯片作为他克莫司节约药的物质基础及对CYP3A和P-GP通路的相关机制研究. 编号：20100171120058，高等学校博士学科点专项科研基金（新教师基金课题），3.6万元，2011.01～2013.12，负责。
“肺与大肠相表里”脏腑相关理论的应用基础研究，第七课题，基于药代动力学和代谢组学的肺与大肠相表里的归经药物研究. 编号：2009CB5227007，国家重点基础研究发展计划（973计划），200万元，2009.01～2013.12，（分题负责人，40万）。
ADME screening techniques and strategies for the evaluation of Chinese Medicines. 编号：RG065/08-09S/ICMS，澳门大学-澳门科学技术发展局联合基金，澳门元52.9万元，2009.01～2010.12，联席项目负责人。
中药五酯片作为他克莫司节约药（Tacrolimus-sparing agent）的机制、物质基础与开发研究. 编号：11A52060010，广州市科技计划项目（科技支撑引导项目），15万元，2011.09～2013.09，负责。
五酯片影响免疫抑制剂他克莫司药动学的机制研究. 编号：B2009049，广东省医学科研基金，0.5万元，2009.01～2010.12，负责。
中药五酯片作为他克莫司节约剂的临床应用与开发研究. 编号：2009164，广东省中医药局“建设中医药强省”科研基金，0.5万元，2009.01～2010.12，负责。
出版专著
《药物临床试验标准操作规程实用指南》.广东科技出版社. 2004.（副主编）
案例版《临床药物代谢动力学》，科学出版社，2010.（参编2万字）
普通高等教育“十一五”国家级规划教材《临床药理学》，高等教育出版社，2010.（参编2万字）
《英汉药物词典》. 商务出版社. 2010年出版. (第一编者，参编5万字)
《量体裁药不是梦——从基因到个体化用药》. 广东科技出版社. 2011.（主编）
发表的SCI论文目录（2006～2011）
Xue Xin-ping, Huang Min, Xiao Huan-yu, Qin Xiao-ling, Zhong Guo-ping, Bi Hui-chang*（通讯作者）. Rapid and simultaneous measurement of in vivo P-glycoprotein and Cytochrome P450 3A activity by liquid chromatography/tandem mass spectrometry based on simultaneous assay of midazolam, 1’-hydroxymidazolam and digoxin. Journal of Pharmaceutical and Biomedical Analysis. 2011; 55: 187-193.
Huang Ling, Bi Huichang, Liu Yahe, Wang Yitao, Xue Xinping, Huang Min. CAR-mediated up-regulation of CYP3A4 expression in LS174T cells by herbal compounds. Drug Metabolism and Pharmacokinetics. 2011, 26(4): 331-340.
Xiong Hui-yu, Bi Hui-chang, Wen Yu-guang, Hu Jin-qing, Zhong Guo-ping, Ou Tian-miao, Huang Zhi-shu, Huang Min. Determination of SYUIQ-F05, a novel antitumor drug, in tissues and plasma samples by liquid chromatography-tandem mass spectrometry: application to a tissue distribution study in rat. Chromatographia. 2011, 73(11-12): 1073-1080.
Liu Ya-he, Mo Sui-lin, Bi Huichang[共同第一作者], Hu Bin-fang, Li Chun-guang, Wang Yi-tao, Huang Ling, Huang Min, Zhou Shu-feng. Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study. Xenobiotics, 2011, 41(4):259-280.
Lan Tian, Bi Huichang[共同第一作者], Liu Weihua, Xie Xi, Xu Suowen, Huang Heqing. Simultaneous determination of sphingosine and sphingosine 1-phosphate in biological samples by liquid chromatography–tandem mass spectrometry. Journal of Chromatography B. 879 (2011) 520–526.
Jin Jing, Bi Hui-chang, Hu Jin-qing, Zeng Hang, Zhong Guo-ping, Zhao Li-zi, Huang Zhi-ying, Huang Min. Effect of Wuzhi Tablet (Schisandra sphenanthera extract) on the Pharmacokinetics of Paclitaxel in rats. Phytotherapy Research. Jan 25, 2011. [Epub ahead of print]
Jing Wanghui, Song Yelin, Yan Ru, Bi Huichang, Li Pengtao, Wang Yitao. Transport and metabolism of (±)-praeruptorin A in Caco-2 cell monolayers. Xenobiotica. 2011, 41(1): 71-81.
Ding Liang, Zhang Fang-bin, Liu Hui, Gao Xiang, Bi Hui-chang, Wang Xue-ding, Chen Bai-li, Zhang Yu, Zhao Li-zi, Zhong Guo-ping, Hu Ping-jin, Huang Min. Hypoxanthine guanine phosphoribosyltransferase activity is related with 6-thioguanine nucleotides concentrations and thiopurine-induced myelosuppression in the treatment of inflammatory bowel disease. Inflammatory Bowel Diseases. Jan 18, 2011. Accepted.
Qin Xiao-ling, Bi Hui-chang[共同第一作者], Wang Xueding, Li Jiali, Wang Ying, Xue Xinping, Xu Lejia, Chen Xiao, Wang Changxi, Wang Yitao, Huang Min*. Mechanistic understanding of the different effects of Wuzhi Tablet (Schisandra sphenanthera extract) on the absorption and first-pass intestinal and hepatic metabolism of Tacrolimus (FK506). Int J Pharm. 2010, 389(1-2):114-121.
Qin Xiao-ling, Bi Hui-chang[共同第一作者], Wang Changxi, Li Jiali, Wang Xueding, Liu Longshan, Chen Xiao, Huang Min*. Study of the effect of Wuzhi tablet (Schisandra sphenanthera extract) on tacrolimus tissue distribution in rat by liquid chromatography tandem mass spectrometry method. Biomed Chromatogr. 2010, 24(4):399-405.
Tang Cheng, Bi Hui-chang[共同第一作者], Zhong Guo-ping, Chen Xiao, Huang Zhi-ying, Huang Min*. Simultaneous determination of mifepristone and monodemethyl-mifepristone in human plasma by liquid chromatography-tandem mass spectrometry method using levonorgestrel as an internal standard: application to a pharmacokinetic study. Biomed Chromatogr. 2009; 23(1):71-80.
He Lin, He Fan, Bi Huichang, Li Jiankang, Zeng Su, Luo Hai-Bin, Huang Min. Isoform-selective inhibition of chrysin towards human cytochrome P450. Kinetics analysis, molecular docking, and molecular dynamics simulations. Bioorg. Med. Chem. Lett. 2010, 20(20): 6008-6012.
Lan Tian, Bi Huichang, Xu Suowen, Le Kang, Xie Zhiyong, Liu Yiwei, Huang Heqing. Determination of sphingosine kinase activity in biological samples by liquid chromatography-tandem mass spectrometry. Biomed Chromatogr. 2010, 24(10):1075-1083.
Jin Jing, Bi Huichang, Hu Jinqing, Zhong Guoping, Zhao Lizi, Huang Zhiying, Huang Min*. Altered Pharmacokinetics and Bioavailability of Paclitaxel after Oral Administration of Schisandrol B in Rats. Biopharm Drug Dispos. 2010, 31(4):264-268.
Cen HJ, Zeng WT, Leng XY, Huang M, Chen X, Li JL, Huang ZY, Bi Hui-chang, Wang XD, He YL, He F, Zhou RN, Zheng QS, Zhao LZ. CYP4F2 rs2108622: a minor significant genetic factor of warfarin dose in Han Chinese patients with mechanical heart valve replacement. Br J Clin Pharmacol. 2010 Aug;70(2):234-240.
Wang Yixi, Wang Changxi, Li Jiali, Wang Xueding, Zhu Genglong, Chen Xiao, Bi Huichang, Huang Min*. Effect of genetic polymorphisms of CYP3A5 and MDR1 on Cyclosporine concentration during the early stage after renal transplantation in Chinese Patients co-treated with diltiazem. Euro J Clin Pharmaco, 2009, 65(3):239-247.
Bi Hui-chang, Zuo Zhong, Chen Xiao, Xu Chen-shu, Wen Ying-ying, Huang Min*. Preclinical factors affecting the pharmacokinetic behaviour of tanshinone IIA, an investigational new drug isolated from Salvia miltiorrhiza for the treatment of ischaemic heart diseases. Xenobiotica. 2008; 38(2): 185-222.
Pan Ying, Bi Hui-chang, Zhong Guo-ping, Chen Xiao, Zuo Zhong, Zhao Li-zi, Gu Lian-quan, Liu Pei-qing, Huang Zhi-ying, Zhou Shu-feng, Huang Min*. Pharmacokinetic characterization of hydroxylpropyl-beta-cyclodextrin-included complex of cryptotanshinone, an investigational cardiovascular drug purified from Danshen (Salvia miltiorrhiza). Xenobiotica. 2008; 38(4):382-98.
Deng Ying, Bi Hui-chang, Zhao Li-zi, Wang Xue-ding, Chen Jie, Ou Zhi-min, Ding Liang, Xu Le-jia, Guan Su, Chen Xiao, Zhou Shu-feng, Huang Min*. Induction of Cytochrome P450 3A by the Ginkgo biloba Extract and Bilobalides in Human and Rat Primary Hepatocytes. Drug Metab Letters. 2008; 2(1): 60-66.
Deng Ying, Bi Hui-chang, Zhao Li-zi, He Fan, Liu Yan-qing, Yu Jia-jun, Ou Zhi-min, Ding Liang, Chen Xiao, Huang Zhi-ying, Zhou Shu-feng, Huang Min*. Induction of cytochrome P450s by terpene trilactones and flavonoids of the Ginkgo biloba extract EGb 761 in rats. Xenobiotica. 2008; 38(5):382-398.
Zhao Li-Zi, Zhong Guo-Ping, Bi Hui-Chang, Ding Liang, Deng Ying, Guan Su, Chen Xiao, Huang Zhi-ying, Huang Min*. Determination of levonorgestrel in human plasma by liquid chromatography-tandem mass spectrometry method: application to a bioequivalence study of two formulations in healthy volunteers. Biomed Chromatogr. 2008; 22(5):519-26.
Bi Hui-chang, Law Francis C.P., Zhong Guo-ping, Xu Chen-shu, Pan Ying, Ding Liang, Chen Xiao, Zhao Li-zi, Xu Qiong, Huang Min*. Study of tanshinone IIA tissue distribution in rat by liquid chromatography-tandem mass spectrometry method. Biomed Chromatogr. 2007; 21(5):473-479.
He Fan, Bi Hui-chang, Xie Zhiyong, Zuo Zhong, Li Jiankang, Li Xin, Zhao Li-zi, Chen Xiao, Huang Min*. Rapid determination of six metabolites from multiple cytochrome P450 probe substrates in human liver microsome by liquid chromatography/mass spectrometry: application to high-throughput inhibition screening of terpenoids. Rapid Commun Mass Spectrom. 2007; 21(5): 635-643.
Guan Su, Bi Hui-Chang, Pan Ying, Chen Xiao, Zhou Zhi-wei, Xue Charlie Changli, Li Chunguang, Huang Min, Zhou Shufeng. Determination of cryptotans hi none, a major active component in Salvia miltiorrhiza, in caco-2 monolayers by HPLC with UV detection. Chromatographia. 2007; 66(7-8): 577-582.
Sun Hai-Yan, Guan Su, Bi Hui-Chang, Su Qi-Biao, Huang Wei-Lin, Chowbay B, Huang Min*, Chen Xiao, Li CG, Zhou Shu-Feng. Determination of CH330331, a novel 4-anilinoquinazoline inhibitor of epidermal growth factor receptor tyrosine kinase, in human Caco-2 monolayers by high performance liquid chromatography with ultraviolet detection: Application to a trans-epithelial transport study. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 ; 854(1-2):320-327.
Bi Hui-chang, Zhao Li-zi, Zhong Guo-ping, Zhou Shufeng, Li Bo, Deng Ying, Chen Xiao, Huang Min*. High-throughput determination of carbocysteine in human plasma by liquid chromatography-tandem mass spectrometry method: application to a bioequivalence study of two formulations in healthy volunteers. Rapid Commun Mass Spectrom. 2006; 20(7):1153-1160.
Zhang Jing, Huang Min*, Guan Su, Bi Hui-Chang, Pan Ying, Duan Wei, Chan Sui-Yung, Chen Xiao, Hong Yun-Han, Bian Jin-Song, Yang Hong-Yuan, and Zhou Shufeng. A Mechanistic Study of the Intestinal Absorption of Cryptotanshinone, the Major Active Constituent of Salvia miltiorrhiza. J Pharmacol Exp Ther. 2006; 317(3): 1285-1294.
■ 联系方式
地址：广州市大学城外环东路132号 中山大学药学院
邮编：510006
Email：bihchang@mail.sysu.edu.cn