郭胜海
博士、副教授、硕士生导师
联系方式:shguo@htu.cn
教育与研究经历:
2000.9-2004.7 河南师范大学,化学专业,本科
2004.9-2009.7 中国科学院上海有机化学研究所,有机化学专业,博士
2009.7-2010.8 上海美迪西生物医药有限公司,化学研发部,课题组长
2010.9-至今 河南师范大学,化学化工学院,副教授
主讲课程:
有机合成,有机化学实验
研究领域与兴趣:
1.5-杂芳环取代嘧啶核苷衍生物的高效合成研究
2.过渡金属催化含氮杂环化合物的合成新方法研究
近年来主持的科研项目:
1.国家自然科学基金项目(21202040): 5-杂芳环取代嘧啶核苷类似物的合成新方法及生物活性研究.
代表性成果:
1.Guo,S.;Wang,J.;Guo,D.;Zhang,X.;Fan,X.Highly regioselective and practical synthesis of 1-acyl-5-hydroxypyrazolines and 1-acyl pyrazoles from 1,2-allenic ketones and hydrazides.Tetrahedron 2012,68(38),7768-7774.
2.Guo,S.;Wang,J.;Guo,D.;Zhang,X.;Fan,X.Synthesis of 3,5-disubstituted pyrazoles via cyclocondensation of 1,2-allenic ketones with hydrazines: application to the synthesis of 5-(5-methyl-pyrazol-3-yl)-2'-deoxycytidine.RSC Adv.2012,2(9),3772-3777.
3.Guo,S.;Liu,Y.A facile Zr-mediated multicomponent approach to arylated allylic alcohols and its application to the synthesis of highly substituted indenes and spiroindenes.Org.Biomol.Chem.2008,6(12),2064-2070.
4.Guo,S.;Zhang,H.;Song,F.;Liu,Y.Studies on the zirconium-mediated alkyne–aldehyde coupling reactions: a facile synthesis of stereodefined allylic alcohols and (Z)-2-en-4-yn-1-ols.Tetrahedron 2007,63(9),2009-2018.
5.Guo,S.;Song,F.;Liu,Y.Gold-catalyzed direct amination of allylic alcohols.Synlett.2007,(6),964-968.
6.Liu,Y.;Song,F.;Guo,S.Cleavage of a carbon-carbon triple bond via gold-catalyzed cascade cyclization/oxidative cleavage reactions of (Z)-enynols with molecular oxygen.J.Am.Chem.Soc.2006,128(35),11332-11333.
7.Liu,Y.;Liu,M.;Guo,S.;Tu,H.;Zhou,Y.;Gao.H.Gold-catalyzed highly efficient access to 3(2H)-furanones from 2-oxo-3-butynoates and related compounds.Org.Lett.2006,8(16),3445-3448.
8.Liu,Y.;Zhou,S.;Li,G.;Yan,B.;Guo,S.;etc.Highly efficient brønsted acid-catalyzed cycloisomerizations of alkynes bearing bis(acetoxy) groups to indenyl ketones.Adv.Synth.Catal.2008,350,797-801.