刘巍峰 教授
博士生导师
E-mail:weifliu@sdu.edu.cn
Cellulosic biomass bioconversion group
刘巍峰 Wei-feng LIU, PhD
Professor of Molecular Microbiology & Biochemistry
State Key Laboratory of Microbial Technology
Shandong University, Jinan 250100
Phone: +86-531-88564324 Fax: +86-531-88565610
E-mail:weifliu@sdu.edu.cn
EDUCATION & EXPERIENCE
2005-present Professor, School of Life Science, Shandong Univeristy
2002-2004 Research Fellow, Cancer Research UK, United Kingdom
1998-2001 Research Associate, Center for Cancer Research, Massachusetts Institute of Technology, USA.
1994-1997 Ph.D of Microbioogy, Shandong University
1991-1994 M.S of Microbiology, Shandong Univeristy
1987-1991 B.S of Microbiology, Shandong University
RESEARCH INTERESTS
1) Biological conversion of cellulosic biomass
2) Mechanism of enzymatic catalysis
3) Signal transduction in cellular responses & gene transcription regulation
4) Biodiversity of lignocellulose-degrading microbes
承担课题
主持课题情况：
1. 结晶纤维素水解过程中外切葡聚糖酶持续催化机制的研究，国家自然科学基金，30770063
2. 泛素-蛋白酶体对转录激活因子GAL4调节机制的研究，国家自然科学基金30670027
3. 酶法裂解制备酵母胞壁免疫寡糖，863项目2006AA102342
4. 纤维素酶机制研究， 国家重点实验室重点课题
SELECTED PUBLICATIONS
1) Zhang X, Chen G, Liu W.Reduction of xylose to xylitol catalyzed by Glucose-fructose oxidoreductase from Zymomonas mobilis.
FEMS Letters 2009 Feb 19.
2) Wang F, Li F, Chen G, Liu W. Isolation and characterization of novel cellulase genes from uncultured microorganisms in different environmental
niches. Microbiol Res 2009.
3) Yu S, Qin W, Zhuang G, Zhang X, Chen G, Liu W. Monitoring oxidative stress and DNA damage induced by heavy metals in yeast expressing a redox-sensitive green fluorescent protein. Curr Microbiol, 2009, 58(5):504-510.
4) Zhang X, Wang Y, Wang L, Chen G, Liu W, Gao P. Site-directed mutagenesis of manganese peroxidase from Phanerochaete chrysosporium in
an in vitro expression system. J Biotechnol 2009 139（2）：176-178.
5) Zhang X, Chen G, Liu W. Reduction of xylose to xylitol catalyzed by Glucose-fructose oxidoreductase from Zymomonas mobilis. FEMS Letters
2009 Feb 19
6) Li F, Wang S, Liu W, Chen G. Purification and characterization of poly(l-lactic acid)-degrading enzymes from Amycolatopsis orientalis ssp.
orientalis. FEMS Microbiol Lett. 2008, 282(1):52-8.
7）Ma A, Hu Q, Qu Y, Bai Z, Liu W, Zhuang G. The enzymatic hydrolysis rate of cellulose decreases with the irreversibly adsorbed
cellobiohydrolase I on cellulose. Enzymatic and Microbial Technology 2008，282（1）:52-58.
8) Yao Q, Sun T, Chen G, Liu W.Heterologous expression and site-directed mutagenesis of endoglucanaseCelA from Clostridium thermocellum. Biotech Lett 2007,29 (8):1243-7
9）Liu W, Svejstrup J. Promoter-independent in vitro assembly of an active transcription elongation complex. Progress in Biochimica & Biophysica 2006，33（10）：1000
10) Somesh B, Reid J, Liu W, Søgaard T, Erdjument-Bromage H, Tempst P, Svejstrup J. Multiple mechanisms confining RNA polymerase Ⅱ to polymerase undergoing transcriptional arrest. Cell 2005, 121:913-923