生物大分子国家重点实验室依托于中科院生物物理研究所，1989年经国家计划发展委员会和中国科学院批准成立，1991年1月通过验收并正式对外开放运行。实验室现有35名研究员（其中院士8名；中国科学院“百人计划”入选者19名；国家杰出青年基金获得者5名；“长江学者奖励计划”特聘教授2名）。
主要研究方向：
1.蛋白质三维结构与功能研究；
2.蛋白质功能与折叠原理研究；
3. 生物膜和膜蛋白功能结构研究；
4. 计算与系统生物学；
5. 感染与免疫的分子基础；
6.蛋白质药物与多肽药物主要研究方向
主要发展方向：
着力打造蛋白质研究国家基地；完善技术支撑体系建设，以技术创新推动科学创新；加强学科方向的研讨，凝练出若干世界科学难题，组织力量开展攻关，力争为我国生命科学发展作出历史性贡献。
目前，科技部批准以生物大分子国家重点实验室为基础建设“蛋白质科学国家实验室”。在所领导和全室同仁共同努力和积极推进下，蛋白质科学国家实验室的筹备工作已全面启动。
实验室主任：许瑞明研究员
实验室副主任：陈畅研究员、张凯研究员
实验室秘书：李佳
实验室研究组及其研究方向(Group Leaders)
研究组长 | 研究方向 | |
院士（MCAS）研究组长 | ||
Prof. Dongcai Liang 梁栋材院士 | 1. 3-D Structureand function of protein 2. Structural genomics project. | |
Prof. Fuyu Yang 杨福愉院士 | Lipid-protein interaction of biomembranes (including mitochondrial membranes) | |
Prof. Zhixin Wang 王志新院士 | Physical chemistry of protein, kinetics of enzyme catalysis and regulation, protein-ligand interaction and prediction of protein three-dimensional structure. | |
Prof. Chih-chen Wang 王志珍院士 | 1. Structure and function of molecular chaperones and folding enzymes. Focus on redox proteins with chaperone and enzyme activities responsible for oxidative folding of proteins in the ER. 2. Fibril formation of neurodegenerative diseases- related proteins and the effect of chaperones on it. 3. Relationship of protein quality control system (ubiquitin-proteasome system and HDAC6) and Pathogenesis of Parkinson\'s disease in transgenic Drosophila model. 4. Protein folding and unfolding studied by using techniques of single molecule, FRET, FTIR etc. | |
Zihe Rao, Professor 饶子和院士 | Structure, function and drug discovery studies targeting important viral and tumor related proteins. | |
Prof. Wenrui Chang 常文瑞院士 | Research of the relationship between 3-D structure and function of photosynthesis membrane proteins based on X-ray crystallography | |
Prof. Dacheng Wang 王大成院士 | Structural biology, mainly on the three-dimensional structure, the relationship between 3D structure and biological function, and engineering of some significant proteins, by using X-ray crystallography and NMR spectrometry | |
研究员研究组长 （按姓氏拼音字母顺序排序） | ||
C | ||
Prof. Chang Chen 陈 畅研究员 | Bioactivity of nitric oxide and redox-based protein thiol modification; Natural product development; Functional study of phosphatidylinositol 4-kinase type IIα (PI4KIIα) and S-nitrosoglutathione reductase (GSNOR) in transgenic mice. | |
| F | ||
Prof. Wei Feng 冯巍研究员 | 1) Structural and functional studies of neuronal scaffold proteins; 2) Structural dissection of protein complexes/machineries involved in the control of cell polarity; 3) Structural basis of molecular motor-mediated cellular trafficking/cargo transport. | |
| H | ||
Prof. Yihua Huang 黄亿华研究员 | Research in my lab focuses on three related areas at the interface between structural biology and bacterial pathology. A. Macromolecules transport across cell membranes B. Molecular details of bacterial protein secretion machineries C. Mechanisms of membrane protein biogenesis | |
J | ||
Prof. Guangju Ji 姬广聚研究员 | 1.Biology of Embryonic Stem Cell 2.Ion Channels and the Mechanism of Ca2+ Movement 3.Cardiac and Smooth Muscle Cell & Molecular Biology 4.Cardiovascular Physio-pathology | |
Prof. Tao Jiang 江 涛研究员 | Structural and functional studies targeting cell surface receptor complexes, membrane proteins and DNA repair proteins | |
L | ||
Prof. Guohong Li 李国红研究员 | we are mainly focusing on the biological functions of chromatin structure in transcriptional egulation of gene. We are interested in understanding: 1) chromatin structures and molecular mechanisms of epigenetics; 2) the roles of chromatin organizations and nuclear architecture in gene regulation, disease and ageing. | |
Prof. Guanghui Liu 刘光慧研究员 | 1.Modeling human diseases with pluripotent stem cells (PSCs); 2.Editing human genome in hPSCs; 3.Mechanism of human aging; 4.Nuclear architecture, chromatin organization, and human diseases. | |
| Prof.Pingsheng Liu 刘平生研究员 | signal transduction and lipid metabolism | |
Prof.Yingfang Liu 刘迎芳研究员 | Structural biology studies of some proteins related to cancer, aging and apoptosis. | |
Prof. Zhijie Liu 刘志杰研究员 | (1) Structural and functional analysis of human signal transcription and activation related proteins; (2) Photoprotein\'s bioluminescent mechanism and its application; (3) Structural proteomics of Human liver disease related proteins; (4) Development of new methods and new technologies in protein X-ray crystallography. | |
Prof. Zhenfeng Liu 柳振峰研究员 | Studing structure and function of membrane proteins from different biological systems, using (but not limited to) the techniques of X-ray crystallography and Cryo-electron Microscopy. | |
| M | ||
Prof. Yue Ma 马 跃研究员 | Human ES cell | |
| O | ||
Prof. Guangshuo Ou 欧光朔研究员 | Understanding how cytoskeleton and signaling-related biomacromolecules regulate neural progenitors to divide, migrate, differentiate and die using Caenorhabditis elegans as the model system. | |
P | ||
Prof. Sarah Perrett 柯 莎研究员 | The yeast protein Ure2 and chaperones | |
S | ||
Prof. Fei Sun 孙 飞研究员 | Use cryoelectron microscopy, single particle three-dimensional reconstruction and X-ray crystallography to study the structures and functions of membrane proteins, macromolecular complexes and protein machineries | |
X | ||
Prof. Ruiming Xu 许瑞明研究员 | The main research focus of our group is on structural studies of gene expression and regulation. Two themes of investigation include epigenetic control of gene transcription and mRNA processing:1. Epigenetic control gene expression.2. RNA processing and protein-RNA interaction | |
Prof. Tao Xu 徐 涛研究员 | The study of the molecular mechanism of insulin release and its modulation；The process of the transport and fusion of the glucose transporter in adipocyte cells；Calcium homeostasis and how it modulates secretion in beta cell and adipocytes. | |
Z | ||
Prof. KaiZhang 张凯研究员 | focusing on structure studies of membrane proteins and proteincomplexes involved in signal transduction and intracellular trafficking. | |
Prof. RongguangZhang 张荣光研究员 | Our laboratory studies the structure and function of the proteins related to important biological processes or human diseases. Our technical advantage is synchrotron radiation x-ray source, based on which we will develop new technologies and methods for structural biology. | |
Prof. Zheng Zhou 周政研究员 | Our lab is interested in how histone variants and histone chaperons, the key players in histone metabolism,regulate the changes of chromatin structure within the context of the broad intra- or inter-molecules interactions. Our current study will focuses on (1) mechanism of histone variants recognition by histone chaperons, (2) mechanism of histone variants displacement, (3) structural basis of histone variant with distinct function. | |
Prof.PingZhu 朱平研究员 | focusing on the research of the structure and function of macrobiomolecules and their complexes using cryo electron microscopy (cryoEM), especially cryo electron tomography (cryoET). | |