姓名：雷鸣
单位：化学系
职称：副教授（自然科学）
基本信息
个人简介
陕西西安人。1999年9月~2002年6月在浙江大学化学系有机化学和药物化学研究所博士；2002年7月~2004年5月浙江大学浙江海正药业（HISUN PHARMA．）博士后工作站博士后；2004年6月浙江大学化学系化学生物学和药物化学研究所副教授、硕士生导师；2009年6月被聘为浙江省医学分子影像重点实验室、浙江大学医学PET中心客座教授。2012年3月～2013年4月澳大利亚联邦科学与工业研究组织（CSIRO）化学与材料科学工程（CMSE Clayton）研究院访问学者。
工作研究领域
1．有机光电材料和有机合成方法学研究
2．分子影像探针合成
3．药物多晶型及相关质量控制研究
联系方式
电话：13857190559，0571-87952359
电子信箱：leiming@zju.edu.cn
教学工作
主讲课程：
综合化学实验
基础化学实验Ⅲ
有机化学
发表论文
2013
Shusheng Li, Ming Lei,* Menglan Lv, Scott E. Watkins, Zhan’ao Tan*, Jin Zhu, Jianhui Hou, Xiwen Chen* and Yongfang Li*,[6,6]-Phenyl-C61- Butyric Acid Dimethylamino Ester as Cathode Buffer Layer for High Performance Polymer Solar Cells, Adv. Energy Mater. DOI: 10.1002/aenm.201300425.
Ming Lei,* Ruijun Hu, Yanguang Wang, and Hong Zhang* Synthesis of 1,4-Disubstituted-1,2,3-trizazoles via Click Reaction in Micro Flow Reactor Heterocycles (accepted) .
2012
Ming Lei,* Wei Li, Ruijun Hu, Yanguang Wang, and Hong Zhang* Synthesis of benzimidazoles in microfluidic chip reactor Heterocycles 2012, 86, 777-783.
Ming Lei*, Zujin Zhan, Wan Tian, Ping Lu One-pot, three-component synthesis of highly functionalized 1,3-oxazine derivatives fromα,β-unsaturated imine, alkyne, and aldehyde Tetrahedron2012, 68(16): 3361-3367.
Ming Lei,* Wan Tian, Ruijun Hu, Wei Li, Hong Zhang Efficient Synthesis of 2-(trifluoromethyl)-2H-[1,3 oxazino[2,3-a]isoquinolines in a Continuous Flow Microreactor via Three-component Cascade Approach Synthesis 2012, 44, 2519-2526 .
2011
Ming Lei*, Wang-Ze Song, Zu-Jin Zhan, Sun-Liang Cui and Fang-Rui Zhong Stereo- and Regioselective Three-Component Reaction in Water: Synthesis of Triazole Substituted β-Lactams Via Click Reaction Lett. Org. Chem. 2011, 8, 163-169.
Lei, Ming*, Zhan, Zujin, Chen, Xiaowei, Zhou, Yanshui, Zhang, Zhizhong Kinetics Study of the Synthesis of 1,3-Diamino-1,2,3-trioximinopropane from the Reaction of Malononitrileoxime with Hydroxylamine ACTA CHIMICA SINICA 2011, 69(9): 1131-1134.
Chen, Xiaowei, Zhan, Zujin, Li, Purui, Ge, Zhongxue, Lei, Ming* Kinetics Study of the Synthesis of Butyl(2-azidoethyl)nitramine from the Reaction of2-[butyl(nitro)amino]ethyl nitratefrom with Sodium azide ACTA CHIMICA SINICA 2011, 69(20): 2523-2526.
2010
Song W Z, Lei M, Shen Y, Wang Y G, et al. Copper-catalyzed four-component reaction of Baylis-Hillman adducts with alkynes, sulfonyl azides and alcohols Adv. Synth. Catal.2010, 352(15): 2432-2436.
Lei M*, Tian M, Zhang H, Click labeled peptides with fluorine-18 for PET imaging Curr. Med. Imaging Rev. 2010, 6(1): 33-41.
2009
Hong D, Lin X F, Zhu Y X, Lei M, Shen Y, Wang Y G, et al. Copper-catalyzed tandem nucleophilic ring opening/intramolecular oxidative amidation of N-tosylaziridines and hydrazones under aerobic conditions Org. Lett. 2009, 11(24): 5678-5681.
Hu R J, Lei M*, Wei H G, Wang Y G, Ionic liquid-H2O resulting in a highly chemoselective oxidation of benzylicalcohols in the presence of aliphatic analogues catalyzed by immobilized TEMPO Chin. J. Chem. 2009, 27(3): 587-592.
Lei M*, Wu D D, Wei H G, Wang Y G, Polymer-supported 4-aminoformoyl-diphenylammonium triflate (PS-AFDPAT): an effective and recyclable catalyst for the biginelli reaction Synthetic Comm. 2009, 39(3): 475-483.
2008
Hu R J, Lei M*, Xiong H S, Mu X, Wang Y G, Yin X F, Highly selective acylation of ferrocene using microfluidic chip reactor Tetrahedron Lett. 2008, 49(2): 387-389.
2007
Tao X L, Lei M*, Wang Y G, Ionic liquid supported synthesis of β-lactam library in ionic liquid batch Tetrahedron Lett. 2007, 48(29): 5143-5146.
Tao X L, Lei M*, Wang Y G, Unexpected microwave reaction of 1,3-disubstituted imidazolium salts: a novel synthesis of 1,3-disubstituted imidazole-2-thiones Synthetic Comm. 2007, 37(1): 399-408.
2006
Lei M, Hu R J, Wang Y G,Mild and selective oxidation of alcohols to aldehydes and ketones using NaIO4/TEMPO/NaBr system under acidic conditions Tetrahedron2006, 62(38): 8928-8932.
Huang J Y, Lei M, Wang Y G, A novel and efficient ionic liquid supported synthesis of oligosaccharides Tetrahedron Lett. 2006, 47(18): 3047-3050.
Lei M*, Tao X L, Wang Y G, A practical, water-soluble, ionic scavenger for the solution-phase syntheses of amides Helvetica Chimica Acta 2006, 89(3): 532-536.
专利成果
授权专利：
1．微波辐射合成1，3-二取代眯唑-2-硫酮的方法（CN1300117）
2．1， 3-二取代眯唑-2-硫酮的微波合成方法（CN1294122）
3．溶液相组合合成酰胺和磺酰胺类化合物的纯化方法（CN100334067C）
4．一种制备含有脂肪醇羟基的芳香醛、酮的方法（CN101274882）
5．4位-1H-1，2，3-三唑-β-内酰胺衍生物的用途（CN 201210009365．1）
公开专利：
1．18F标记肿瘤抑制剂Monastrol的前体化合物及制备方法和用途（CN101781259）
2．一种三氮唑类化合物及其制备方法（CN 101768125A）
3．4位-1H-1，2，3-三唑-β-内酰胺衍生物及其制备方法 （CN 101665509）
4．4位-1H-1，2，3-三唑-β-内酰胺衍生物及制备方法 （CN101665508）
5．4位-1H-1，2，3-三唑-β-内酰胺衍生物的用途（CN 201210132453．0）
学术交流（讲座报告）
2013．3．29 澳大利亚CSIRO，CMSE-Clayton
Access to heterocyclic compounds via one-pot multi-component reactions and development of cathode interlayer material for polymer solar cells