第四军医大学药学系硕导介绍:张邦乐_-查字典考研网
 
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第四军医大学药学系硕导介绍:张邦乐

考研时间: 2012-10-04 来源:查字典考研网

张邦乐, 第四军医大学药学系药剂学教研室副教授,硕士生导师,国家执业药师。分别于西北大学、第四军医大学和中科院上海药物研究所获有机合成学士学位、药理学硕士学位和药物化学博士学位, 先后工作于第四军医大学生产管理局科研药厂、化学及药理学教研室。

作为课题负责人承担十二五国家“重大新药创制”科技重大专项课题1项、国家自然科学基金课题1项、企业横向合作课题1项,分题负责十一五国家“重大新药创制”课题2项;以主要完成人参与完成国家863课题2项,国家自然科学基金4项,军队省部重点、攻关研究课题10余项。近年来发表科研论文50余篇(其中SCI收录期刊30余篇),获学会优秀论文奖1次;获国家发明专利2项,申请4项。先后主讲有机化学、药理学、药物化学、药剂学、药学研究新进展、临床药理学等课程,发表教学论文7篇,主编校内教材3部。曾多次获嘉奖并荣立个人“三等功”1次,2011年获精英人才“青年英才支持计划(第一层次)”研究基金资助。

自工作以来一直从事药物设计及临床前药学、药理学与药物动力学研究工作,在药用新辅料及新剂型研究,新药设计、活性天然产物分离与结构修饰等方面开展工作。

研究方向和主要工作包括以下几个方面:

(1)药用新辅料及制剂新技术研究:结肠、骨和脑靶向给药系统,自乳化给药系统及其体内药物动力学研究;互穿网络壳聚糖-PEG药用新辅料及其在多肽类药物稳定化和缓控释制剂设计中的应用;靶向脂质体研究。

(2)药物设计合成及构效关系研究:COX-2选择性抑制剂及其前体药物抗炎、镇痛及抗肿瘤活性研究;慢性炎性疾病和抗肿瘤生物活性天然产物的基础及应用研究;提高军事作业能力军队特需药物研究。

近年发表的主要论文:

1. Bang-Le Zhang, Cheng-Qi Fan, Lei Dong, Fang-Dao Wang, Jian-Min Yue. Structural modification of a specific antimicrobial lead against Helicobacter pylori discovered from traditional Chinese medicine and a structure activity relationship study. European Journal of Medicinal Chemistry, 2010, 45, 5258-5264.

2. Bang-le Zhang, Wei He, Xin Shi, Meng-lei Huan, Qiu-ju Huang, Si-yuan Zhou. Synthesis and biological activity of the calcium modulator (R) and (S)-3-methyl 5-pentyl 2,6-dimethyl- 4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate. Bioorganic & Medicinal Chemistry Letters, 2010, 20, 805-808.

3. Bangle Zhang, Wei He, Xiaoli Sun. eLetter for pharmacogenetics and pharmacogenomics of anticancer agents (Comment). CA: A Cancer Journal for Clinicians, June 17, 2009, 59, 42.

4. Siyuan Zhou, Bangle Zhang(Co-first author), Xinyou Liu, Zenghui Teng, Menglei Huan, Tiehong Yang, Zhifu Yang, Min Jia, Qibing Mei. A new natural angelica polysaccharide based colon-specific drug delivery system. Journal of Pharmaceutical Sciences. 2009, 98, 4756-4768.

5. Hua Li, Si-Wang Wang*, Bang-Le Zhang*, Yan-Hua Xie, Qian Yang, Wei Caoa, Jian-Bo Wang. Simultaneous quantitative determination of 9 active components in traditional Chinese medicinal preparation ShuangDan oral liquid by RP-HPLC coupled with photodiode array detection. Journal of Pharmaceutical and Biomedical Analysis, 2011, 56, 820-824.

6. Hua Li, Siwang Wang*, Qian Yang, Yanhua Xie, Wei Cao, Bangle Zhang*, Jianbo Wang, Jiepin Wang and Meng Wang. LC Tissue distribution study of paeonol in rats after oral administration. Chromatographia, 2011, 73, 495-500.

7. Yu Wei, Bang-Le Zhang, Peng Liu, Wei He, Sheng-Yong Zhang. The application of chiral schiff base in asymmetric catalysis. Mini-Reviews in Organic Chemistry, 2011, 8, 66-90.

8. Hua Li, Siwang Wang*, Bangle Zhang*, Yanhua Xie, Jianbo Wang, Qian Yang, Wei Cao, Jing Hu, Linrui Duan. Influence of co-administered danshensu on pharmacokinetic fate and tissue distribution of paeonol in rat. Planta Medica, 2011, 77, 1-6(DOI http://dx.doi.org/ 10.1055/s-0031-1280269).

9. Bang-Le Zhang, Fang-Dao Wang, Jian-Min Yue. Concise and efficient synthesis of linear furocoumarins: psoralen and 4-methylpsoralen. Synthetic Communications, 2007, 37, 63-70.

10. Bang-Le Zhang, Fang-Dao Wang, Jian-Min Yue. A new efficient method for the total synthesis of linear furocoumarins. Synlett, 2006, 4, 567-570.

11. Bang-Le Zhang, Jia-Min Yue. Catecholborane, a convenient boron reagent. Synlett, 2007, 4, 666-667.

12. Sheng-Ping Yang, Yu-Jun Cai, Bang-Le Zhang, Lin-Jiang Tong, Hua Xie, Yan Wu, Li-Ping Lin, Jian Ding, and Jian-Min Yue. Structural modification of an angiogenesis inhibitor discovered from Traditional Chinese Medicine and a structure–activity relationship study. Journal of Medicinal Chemistry, 2008, 51, 77–85.

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