姓名：胡容 性别：女
职称：教授 学院：药学院
研究方向：肿瘤药理学
学习、工作经历
2008年-今 中国药科大学生理教研室 教授
1999年-2005年 美国Rutgers University 药学博士
主要科研工作简介：
具体研究领域
在美国Rutgers大学留学期间主要从事肿瘤的化学预防药物研究，已发表相关SCI论文二十余篇，开发的结肠癌预防药物在美国已进入II期临床。现阶段主要研究方向是：1）从天然产物中寻找新型化学预防药物并进行机制研究；2）在细胞、分子和整体水平上，建立基于阻断“炎-癌转化”的新型肿瘤预防药物的药效学评价体系，为发现更多高效低毒的肿瘤预防药物奠定基础；3）肿瘤多药耐药的逆转及其机制研究。
课题资助
国家自然科学基金，江苏省自然科学基金，863计划重大项目基金，国家新药创制重大专项平台等
近期代表性论文
1. Rong JJ, Hu R (co-contributing author), Qi Q, Gu HY, Zhao Q, Wang J, Mu R, You QD, Guo QL. Gambogic acid down-regulates MDM2 oncogene and induces p21(Waf1/CIP1) expression independent of p53. Cancer Lett. 2009 May 8. [Epub ahead of print]
2. Sun Y, Lu N, Ling Y, Gao Y, Chen Y, Wang L, Hu R, Qi Q, Liu W, Yang Y, You Q, Guo Q. Oroxylin A suppresses invasion through down-regulating the expression of matrix metalloproteinase-2/9 in MDA-MB-435 human breast cancer cells. Eur J Pharmacol. 2009 Jan 28; 603(1-3):22-8.
3. Peng J, Qi Q, You Q, Hu R, Liu W, Feng F, Wang G, Guo Q. Subchronic toxicity and plasma pharmacokinetic studies on wogonin, a natural flavonoid, in Beagle dogs. J Ethnopharmacol. 2009 Jul 15;124(2):257-62.
4. Shen G, Khor TO, Hu R, Yu S, Nair S, Ho CT, Reddy BS, Huang MT, Newmark HL, Kong AN. Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse. Cancer Res. 2007 Oct 15;67(20):9937-44.
5. Hu R, Khor T, Shen G, Joeng WS, Hebbar V, Chen C, Xu C, Reddy B, Chada K, Kong AN. Cancer Chemoprevention of Intestinal Polyposis in Apc+/Min Mice by Sulforaphane, a Natural Product Derived from Cruciferous Vegetable. Carcinogenesis, 2006 Oct; 27(10):2038-46.
6. Hu R, Xu C, Shen G, Jain MR, Khor TO, Gopalkrishnan A, Lin W, Reddy B, Chan JY, Kong AN. Gene Expression Profiles Induced by Cancer Chemopreventive Isothiocyanate Sulforaphane in the Liver of C57BL/6J Mice and C57BL/6J/Nrf2 (-/-) Mice. Cancer Lett. 2006 Nov 18; 243(2):170-92.
7. Hu R, Xu C, Shen G, Jain MR, Khor TO, Gopalkrishnan A, Lin W, Reddy B, Chan JY, Kong AN. Identification of Nrf2-regulated Genes Induced by Chemopreventive Isothiocyanate PEITC by Oligonucleotide Microarray. Life Sci. 2006 Oct 12;79(20):1944-55.
8. Hu R, Shen G, Hebbar V, Xu C, Lin W, Kong AN. In vivo Pharmacokinetics, Activation of MAP and Regulation of Gene Expression Elicited by Cancer Chemopreventive compound BHA in Mice. Arch Pharm Res. 2006 Oct; 29(10):911-20.
9. Khor TO, Hu R (co-contributing author), Shen G, Jeong WS, Hebbar V, Chen C, Xu C, Nair S, Reddy B, Chada K, Kong AN. Pharmacogenomics of Cancer Chemopreventive Isothiocyanate Compound Sulforaphane in the Intestinal Polyps of ApcMin/+ Mice. Biopharm Drug Dispos. 2006 Dec; 27(9):407-20.
10. Hu R, Hebbar V, Kim BR, Chen C, Winnik B, Buckley B, Soteropoulos P, Tolias P, Hart RP, Kong AN. In Vivo Pharmacokinetics and Regulation of Gene Expression Profiles by Isothiocyanate Suloraphane in the Rat. J Pharmacol Exp Ther. 2004 Jul; 310(1):263-71.
11. Hu R, Kong AN. Activation of MAP kinases, Apoptosis and Nutragenomic of Gene Expression Elicited by Dietary Cancer Prevention Compounds. Nutrition. 2004 Jan; 20 (1): 83-88.
12. Hu R, Kim BR, Chen C, Hebbar V, Kong AN. The Roles of JNK and Apoptotic Signaling Pathways in PEITC-mediated Responses in Human HT-29 Colon Adenocarcinoma Cells. Carcinogenesis. 2003 Aug; 24 (8):1361-7.
13. Kim BR., Hu R, Keum YS, Hebbar V, Shen G, Nair S, Kong AN. Effects of Glutathione on Antioxidant Response Element-mediated Gene Expression and Apoptosis Elicited by Sulforaphane. Cancer Res. 2003 Nov 1; 63(21): 7520-5.