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中国药科大学理学院导师介绍:李嘉宾

考研时间: 2013-08-02 来源:查字典考研网

个人简介:

李嘉宾,男,1972年8月生,副教授,硕士生导师。1993年本科毕业于山西大学化学系有机化学专业,1996年硕士毕业于山西大学分子科学研究所(教育部化学生物学与分子工程重点实验室)生物无机化学专业,2006年博士毕业于中国药科大学药学院药物化学专业。已发表研究性论文15篇,其中SCI源论文8篇。参与了国家863项目《一类抗高血压新药盐酸菲洛普的研究》等三项纵向课题,承担了两项企业委托项目。指导和协助指导研究生6人,已毕业3人。

研究方向:

1. 治疗良性前列腺增生及心脑血管疾病的新药研究。

2. 以GPCR为靶标的活性小分子的设计、合成、生物活性及构效关系研究。

已发表论文:

(1) Jun XIA, Jiabin LI*, Hongbin SUN Insights into ETA subtype selectivity of benzodiazepine endothelin receptor antagonists by 3D-QSAR approaches J. Mol. Model, 2012, 18(4): 1299-1322, DOI 10.1007/s00894-011-1153-x

(2) Lutai WANG, Jiabin LI, Xiaowen XUE* A concise synthesis of ximenynic acid Synth. Commun. 2012, 42, 3540-3543, DOI 10.1080/00397911.2011.585443

(3) Ying Zhang, Liwei Zhang, Jiabin LI* CoMFA model of dihydropyrimidinone α1A-adrenocepter antagonists, J. China Pharmaceutical U. 2010, 41(3): 216-221

(4) Jiabin LI*, Wensheng XUAN, Ju NIU, Zhenzhou JIANG, Tao WANG, Lin XIA Synthesis, biological evaluation and 3D-QSAR study of 1- (1,4-benzodioxan-2-ylcaronyl)-4-aryl oxyalkyl- piperazines as α1-adrenoceptor antagonists J. China Pharmaceutical U. 2010, 41(6): 499-504

(5) Jiabin LI, Haichun LIU, Li ZHANG, Tao WANG, Zhenzhou JIANG, Lin XIA*, Searching for the novel lead compounds of α1-AR antagonists (Part II): synthesis, bioassays and 3D-QSAR of 2-(4-(Aryloxyalkyl)-piperazin-1-yl)benzo[d]oxazole compounds Chem. J. Chinese U., 2009, 30(5): 903-907

(6) Jiabin LI, Zhenzhou JIANG, Tao WANG, Mingming LIU, Jun XIA, Lin XIA, Searching for the novel lead compounds of α1-AR antagonists (Part I): design, synthesis and bioassay of 5-Chloro-2-[4-(aryloxyalkyl)piperazin-1-yl]benzo[d]oxazole compounds Acta Chimica Sinica, 2008, 66(24): 2725-2729

(7) Jiabin LI, Lin XIA*, Bin Wu, Tao Wang, Zhenzhou Jiang Design, synthesis and biological estimation of 1-(Benzoxazole-2-yl) piperazine and 4-(Benzoxazole-2-yl) piperidine derivatives as potential α1-AR antagonists Chinese Chemical Letters 2008, 19(10), 1193-1195

(8) Jiabin LI, Lin XIA*, Yadong CHEN A 3D pharmacophore model of α1A-adrenoceptor antagonists Acta Chimica Sinica, 2007, 65 (16): 1621-1630

(9) Jiabin LI, Lin XIA*, Tao WANG Synthesis and biological activity of 1-(1,4-benzodioxan-2-yl- carbonyl)-4-aryloxyalkylpiperazine as α1-adrenoceptor antagonists Chinese J. Medicinal Chem. 2006, 16 (6): 336-341

(10) Jiabin LI, Lin XIA*, Zhenzhou, JIANG Design ,synthesis and biological activities of 1-(5-t-butyl- 2-benzoxazolemethyl)-4-aryloxyalkylpiperazine as α1 adrenoceptor antagonists J. China Pharmaceutical U. 2006, 37 (2): 114-118

(11) Jiabin LI, Pin YANG*, Fei GAO, Gaoyi HAN, Kaibei YU Novel lanthanide complexes of ciprofloxacin: synthesis, characterization, crystal structure and in vitro antibacterial activity studies Chinese J.Chem., 2001, 19 (6), 598-605

(12) Pin YANG*, Jiabin LI, Yanni TIAN Synthesis and crystal structure of rare earth complex with ciprofloxacin Chinese Chem. Lett., 1999, 10 (10), 879-880

招生对象:

欢迎有志于从事药物化学及合成化学研究的各专业同学报考。

联系方式:

Tel:025-86185171(Lab);Email:jbli@cpu.edu.cn,

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