姓名：张渝君 性别：女
职称：教授 学院：生命科学学院
研究方向：
免疫化学诱导蛋白MCP-1（CCL2）与肝脏疾病的关系及其在肝癌治疗方面的研究；T淋巴细胞白血病发生机理的研究。
电话：028-85418843
Email：yz5357@gmail.com
简历：
·1978, 2-1982, 2 毕业于四川大学生物系生物化学专业获理学学士学位
·1982, 2-1985, 2 毕业于四川大学生物系生物化学专业获理学硕士学位
·1985, 2-1987, 2 四川大学生物系遗传学专业助教
·1987, 2-1992, 2 毕业于美国马萨诸塞大学细胞与发育生物学专业获理学博士学位
·1992, 2-1996, 5 在美国哈佛大学医学院Dana-Farber癌症中心作博士后研究
·1996, 5-2001, 5 任波士顿大学医学院医学系讲师
·2001, 5-2008, 5 任波士顿大学医学院医学系助理教授
·2008, 5-2010, 4 任波士顿大学医学院医学系副教授
·2010, 4- 现在 任四川大学生命科学学院特聘教授
研究内容：
·研究在肝癌细胞中, MCP-1（CCL2）的表达是如何被调控的，有哪些信号传导通路参与
MCP-1（CCL2）表达的调控。
·研究MCP-1（CCL2）与免疫反应的关系以及诱导肝癌细胞凋亡的分子机理。
·筛选MCP-1（CCL2）的抑制剂和拮抗剂, 研究其对肝癌细胞生长的抑制作用和机理。
·研究由于白介素16前体蛋白-p80缺失诱导T淋巴细胞白血病发生的机理。
发表论文：
·Zhang, Y., and Kunkel, J.G. (1992). Modulation of F-actin filaments organization during morphogenesis of insect follicle cell epithelium. Tissue & Cell 24:905-17.
·Zhang, Y., and Kunkel, J.G. (1993). Most egg calmodulin is a follicle cell contribution to the cytoplasm of the oocyte. Dev. Biol. 161:513-21.
·Zhang, Y., Rutledge, B.J. and Rollins, B.J. (1994). Structure/activity analysis of human monocyte chemoattractant protein-1 (MCP-1): identification of a mutated protein that inhibits MCP-1 mediated monocyte chemotaxis. J Biol Chem. 269:15918-24.
· Ernst, C.A., Zhang, Y., Hancock, P.R., Rutledge, B.J., Corless, C.L. and Rollins, B.J. (1994). Biochemical and biological characterization of murine MCP-1: identification of two functional domains. J. Immunol. 152:2541-9.
·Zhang, Y., and Rollins, B.J. (1995). A dominant negative inhibitor indicates that monocyte chemoattractant protein-1 functions as a dimer. Mol. Cell Biol. 15:4851-4855.
·Zhang, Y., Ernst, C.A., Rollins, B.J. (1996). Structure/Activity Analysis. Methods 10:93-10.
·Schecter, A.D., Rollins, B.J., Zhang, Y., Charo, I.F., Fallon, J.T., Rossikhina, M. Giesen, P.L.A., Nemerson, Y., and Taubman, M.B. (1997) Tissue factor is induced by monocyte chemoattractant protein-1 in human aortic smooth muscle and THP-1 cells. J. Biol. Chem. 272:28568-28573.
·Yen, H., Zhang, Y., Penfold, S., and Rollins, B.J. (1997) MCP-1-mediated chemotaxis requires activation of non-overlapping signal transduction pathways. J. Leukocyte Biol. 61:529-532.
·Zhang, Y., Center, D.M., Wu, D.M.H., Cruikshank, W.W., Yuang, J., Andrews, D.W. and Kornfeld, H. (1998). Processing and Activation of pro-IL-16 by caspase 3.
J Biol Chem. 273:1144-1149.
·Keane, J., Nicoll, J., Kim, S., Wu, D.M.H. Cruikshank, W.W., Brazer, W., Natke, B., Zhang, Y., Center, D.M., and Kornfeld, H. (1998) Conservation of Structure and Function Between Human and Murine IL-16. J. Immunol. 160:5945-5954.
·Wu, D.M.HJ., Zhang, Y., Parada, N.A., Kornfeld, H., Nicoll, J., Center, D.M., and Cruikshank, W.W. (1999) Processing and Release of IL-16 from CD4+ But Not CD8+ T Cells Is Activation Dependent. J. Immunol. 162:1287-1293.
·Zhang, Y., Kornfeld, H., Cruikshank, W.W., Kim, S., Reardon, C.C., and Center, D.M.. (2001) Nuclear Translocation of the N-terminal Pro-domain of Interleukin-16. J. Biol. Chem. 276:1299-1303.
·Wilson, K.C., Cruikshank, W.W., Center, D.M., and Zhang, Y.. (2002). The N-terminal Domain of Prointerleukin-16 Contains a Functional CcN Motif. Biochemistry. 41: 14306-14312.
· Wilson, K.C., Cruikshank, W.W., Center, D.M., and Zhang, Y.. (2003). HTLV-1 Tax Oncoprotein Binds to the Precursor of Interleukin-16: a PDZ-Containing Protein. Virology 306: 60-67.
·Center, D.M., Cruikshank, W.W., Zhang,Y.. (2004). Nuclear Pro-IL-16 Regulation of T cell Proliferation: p27KIP1-Dependent G0/G1 Arrest Mediated by Inhibition of Skp2 Transcription. J. Immunol. 172 (3):1654-1660.
·Chang, D.L., Qiu, W., Ying, H., Zhang, Y., Chen, C.Y., and Xiao, Z.X.. (2007). ARF Promotes Accumulation of Retinoblastoma Protein through Inhibition of MDM2. Oncogene 26:4627-4634.
·Zhang, Y., Tuzova, M., Xiao, Z.X., Cruikshank, W.W., and Center, D.M.. (2008). Pro-Interleukin-16 recruits Histone Deacetylase 3 to the Skp2 Core Promoter through Interaction with Transcription Factor GABP. J. Immunol. 180:402-408.
·Qiu, W., Wu, J., Walsh, W. M., Zhang, Y., Chanr, C-Y., Fujita, J., and Xiao ZX. (2008). Retinoblastoma protein modulates gankyri-MDM2 in regulation of p53 stability and chemosensitivity in cancer cells. Oncogene 27:4034-4043.
专利：
·Rollins,B.J. and Zhang,Y.，“Human monocyte chemottractant protein-1 (MCP-1) derivatives” (US Patent Number: 5,459,128)。
·Rollins,B.J. and Zhang,Y. Chemokine N-Terminal Deletion Mutations (US Patent Number: 5,739,103).