| 姓名： | 郑辉 | 性别： | 男 |
| 职务： | 职称： | 研究员 | |
| 学历： | 博士 | 通讯地址： | 广州市开源大道190号 |
| 电话： | 邮政编码： | 510530 | |
| 传真： | 电子邮件： | zheng_hui@gibh.ac.cn |
简历：
2001-2005 清华大学生物科学与技术系 学士学位
2005-2010美国明尼苏达大学药理系 博士学位
2010-2010美国明尼苏达大学药理系 博士后
2010-至今 中国科学院广州生物医药与健康研究院 研究员
研究领域：
1．神经干细胞与学习和记忆
2．吗啡受体的信号通路和成瘾性研究
3．胆固醇对于G蛋白偶联受体信号通路的影响
代表论著：
As Corresponding Author：
11．Zheng，H．*，Zhang，Y．，Li，W．，Loh，H．H．& Law，P．Y．（2012）NeuroD modulates opioid agonist-selective regulation of adult neurogenesis and contextual memory extinction Neuropsychopharmacol Accepted．
10．Zheng，H．*，Zou，H．，Liu，X．，Chu，J．，Zhou，Y．，et al．（2012）Cholesterol level influences opioid signaling in cell models and analgesia in mice and humans J Lipid Res 53，1153-62．
09．Zheng，H．*，Pearsall，E．A．，Hurst，D．P．，Zhang，Y．，Chu，J．，et al．（2012）Palmitoylation and membrane cholesterol stabilize mu-opioid receptor homodimerization and G protein coupling BMC Cell Biol 13，6．
08．Zheng，H．*，Law，P．Y．& Loh，H．H．（2012）Non-Coding RNAs Regulating Morphine Function：With Emphasis on the In vivo and In vitro Functions of miR-190 Front Genet 3，113．
07．Zheng，H．*，Chu，J．，Zhang，Y．，Loh，H．H．& Law，P．Y．（2011）Modulating micro-opioid receptor phosphorylation switches agonist-dependent signaling as reflected in PKCepsilon activation and dendritic spine stability J Biol Chem 286，12724-33．
06．Zheng，H．*，Chu，J．，Zeng，Y．，Loh，H．H．& Law，P．Y．（2010）Yin Yang 1 phosphorylation contributes to the differential effects of mu-opioid receptor agonists on microRNA-190 expression J Biol Chem 285，21994-2002．
05．Zheng，H．*，Loh，H．H．& Law，P．Y．（2010）Agonist-selective signaling of G protein-coupled receptor：Mechanisms and implications IUBMB Life 62，112-119．
04．Zheng，H．*，Zeng，Y．，Chu，J．，Kam，A．Y．，Loh，H．H．，et al．（2010）Modulations of NeuroD activity contribute to the differential effects of morphine and fentanyl on dendritic spine stability J Neurosci 30，8102-10．
03．Zheng，H．*，Zeng，Y．，Zhang，X．，Chu，J．，Loh，H．H．，et al．（2010）{micro}-Opioid Receptor Agonists Differentially Regulate the Expression of miR-190 and NeuroD Mol Pharmacol 77，102-109．
02．Zheng，H．*，Chu，J．，Qiu，Y．，Loh，H．H．& Law，P．Y．（2008）Agonist-selective signaling is determined by the receptor location within the membrane domains Proc Natl Acad Sci U S A 105，9421-6．
01．Zheng，H．*，Loh，H．H．& Law，P．Y．（2008）（1）-Arrestin-Dependent {micro}-Opioid Receptor-Activated Extracellular Signal-Regulated Kinases （ERKs）Translocate to Nucleus in Contrast to G Protein-Dependent ERK Activation Mol Pharmacol 73，178-90．
Others：
04．Wu，Q．*，Hwang，C．K．，Zheng，H．，Wagley，Y．，Lin，H．Y．et al．，（2012）MicroRNA 339 down-regulates mu-opioid receptor at the post-transcriptional level in response to opioid treatment FASEB J [Epub ahead of print]
03．Chu，J．*，Zheng，H．，Loh，H．H．& Law，P．Y．（2008）Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestins Cell Signal 20，1616-24．
02．Chu，J．*，Zheng，H．，Zhang，Y．，Loh，H．H．& Law，P．Y．（2010）Agonist-dependent mu-opioid receptor signaling can lead to heterologous desensitization Cell Signal 22，684-96．
01．Pan，G．，Li，J．，Zhou，Y．，Zheng，H．& Pei，D*．（2006）A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal Faseb J 20，1730-2．