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中科院广州生物研究院导师介绍:陈小平

考研时间: 2013-08-16 来源:查字典考研网

姓名:陈小平性别:
职务:职称:研究员
学历:博士通讯地址:广州萝岗区科学城开源大道190号
电话:邮政编码:510530
传真:电子邮件:chen_xiaoping@gibh.ac.cn

简历:

1995-1998 中山医科大学病原生物学博士

1997-1997 美国加州大学(UCLA)医学院访问学者

1985-1988 中山医科大学传染病学硕士

1977-1980 广东医学院临床医学系

2004-现在中国科学院广州生物医药与健康研究院,研究员

2001-2004 广州市疾病预防控制中心艾滋病研究室主任,研究员

1998-2001 广州市疾病预防控制中心艾滋病研究室主任,副研究员

1994-1995 广州市疾病预防控制中心微生物科主任,副研究员

1988-1994 广州市疾病预防控制中心流行病科、病毒免疫科、微生物科助理研究员

1980-1985 广东医学院附属第一医院传染病教研室助教,住院医师

研究领域:

长期目标是研究和开发针对重大传染病和肿瘤防治的创新药物、疫苗和方法。本研究室在建立重大疾病的分子、细胞和动物模型的基础上,重点开展:

1.针对世界三大疾病(疟疾、癌症和艾滋病)的药物与疫苗研发。

2.疟疾与癌症、疟疾与艾滋病的相互作用及其机理研究。

3.癌症和艾滋病的基因和生物治疗研究。

代表论著:

Yao Y,Nashun B,Zhou T,Qin L,Qin L,…Zhao S,Xu J,Esteban M,Chen X.Generation of CD34+ Cells from CCR5-disrupted Human Embryonic and Induced Pluripotent Stem Cells.Human Gene Therapy.2012,23:238-242.

Li Q,Ruan Z,Zhang H,Peng N,Zhao S,Qin L,Chen X.Characterization of peripheral blood T lymphocyte subsets in Chinese rhesus macaques with repeated or long-term infection with Plasmodium cynomolgi.Parasitol Res.2012,110 (2):961-9.

Chen L,He Z,Qin L,Li Q,Shi X,Zhao S,Chen L,Zhong N,Chen X.Antitumor effect of malaria parasite infection in a murine Lewis lung cancer model through induction of innate and adaptive immunity.PLoS ONE.2011,6 (9):e24407.

Li X,He Z,Chen L,Li Y,Li Q,Zhao S,Tao Z,Hu W,Qin L,Chen X.Synergy of the antiretroviral protease inhibitor indinavir and chloroquine against malaria parasites in vitro and in vivo.Parasitol Res.2011;109:1519-1524.

Wang B,Li Q,Qin L,Zhao S,Wang J,Chen X.Transition of tumor-associated macrophages from MHC class IIhi to MHC class IIlow mediates tumor progression in mice.BMC Immunol.2011;12:43.

Li Y,Qin L,Peng N,Liu G,Zhao S,He Z,Chen X.The Antimalarial effect of human immunodeficiency virus protease inhibitors in rhesus macaques.Antimicrob Agents Chemother.2011,55:3039-42.

Jiang B,Qin L,Du Y,Peng N,Chen L,Chen Z,Chen X.Transgenic Plasmodium that expresses HIV-1 Gag elicits immunity and protects mice against vaccinia virus-gag and malarial parasites.Vaccine.2010,28:7915-7922

You J,He Z,Chen L,Deng G,Liu W,Qin L,Qiu F and Chen X.CH05-10,a novel indinavir analog,is a broad spectrum antitumor agent that induces cell cycle arrest,apoptosis,endoplasmic reticulum stress and autophagy.Cancer Science.2010;101:2644-51.

He Z,Chen L,You J,Qin L,Chen X.Antiretroviral protease inhibitors potentiate chloroquine antimalarial activity in malaria parasites by regulating intracellular glutathione metabolism.Exp Parasitol,2009;123:122-127.

Shi X,Qin L,Liu G,Zhao S,Peng N,Chen X.Dynamic balance of pSTAT1 and pSTAT3 in C57BL/6 mice infected with lethal or non-lethal Plasmodium yoelii.Cell Mol Immunol,2008;5:341-348.

He Z,Qin L,Chen L,Peng N,You J and Chen X.Synergy of human immunodeficiency virus protease inhibitors with chloroquine against Plasmodium falciparum in vitro and Plasmodium chabaudi in vivo.Antimicro Agents Chemother.2008;52:2653-56.

Zhang L,Yan K,Zhang Y,Huang R,Bian J,Zheng C,Sun H,Chen Z,Sun N,An R,Min F,Zhao W,Zhuo Y,You J,Song Y,Yu Z,Liu Z,Yang K,Gao H,Dai H,Zhang X,Wang J,Fu C,Pei G,Liu J,Zhang S,Goodfellow M,Jiang Y,Kuai J,Zhou G and Chen X.High-throughput synergy screening identifies beauvericin as a novel combination agent for the treatment of fungal infections.Proc Natl Acad Sci USA.2007;104:4606-4611.

Chen X,Cao Y.Consideration of highly active antiretroviral therapy in the prevention and treatment of severe acute respiratory syndrome.Clin Infect Dis2004;38:1030-1032.

Chen X,Li G,Tang X,et al.Lack of severe acute respiratory syndrome in 19 AIDS patients hospitalized together.J Acquir Immune Defic Syndr 2003;34:242-243.

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